Convert pharmacokinetic parameters for one compartment model

Description

Calculate pharmacokinetic parameters with parameters (A and alpha) in one compartment model "Aexp(-alpha)"

Usage

OneComp_Coefficient_Exponent(A,alpha,A.sd=NA,alpha.sd=NA,
           covar=c(Aalpha=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Coefficient_Exponent(A=0.125,alpha=0.5,A.sd=0.002,alpha.sd=0.009)

Convert pharmacokinetic parameters for one compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution (V1) and clearance (Cl1)

Usage

OneComp_Volume_Clearance(V1,Cl1,V1.sd=NA,Cl1.sd=NA,
        covar=c(V1Cl1=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Gabrielsson and Weiner(2006) Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swedish Academy of Pharmaceutical Sciences.

Examples

OneComp_Volume_Clearance(V1=8,Cl1=4,V1.sd=0.01,Cl1.sd=0.01)

Convert pharmacokinetic parameters for one compartment model

Description

Calculate pharmacokinetic parameters with clearance (Cl1) and half-life (t_alpha)

Usage

OneComp_Volume_Clearance_HalfLife(Cl1,t_alpha,
         Cl1.sd=NA,t_alpha.sd=NA,covar=c(Cl1talpha=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Volume_Clearance_HalfLife(Cl1=4,t_alpha=0.568,
      Cl1.sd=0.01,t_alpha.sd=0.0003)

Convert pharmacokinetic parameters for one compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1) and parameter (alpha) in the model "Aexp(-alpha)"

Usage

OneComp_Volume_Exponent(V1,alpha,V1.sd=NA,alpha.sd=NA,
         covar=c(V1alpha=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Volume_Exponent(V1=8,alpha=0.5,V1.sd=0.01,alpha.sd=0.001)

Convert pharmacokinetic parameters for one compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution (V1) and elimination rate constant (k10)

Usage

OneComp_Volume_RateConstant(V1,k10,
             V1.sd=NA,k10.sd=NA,covar=c(V1k10=0),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Volume_RateConstant(V1=8,k10=0.5,V1.sd=0.01,k10.sd=0.002)

Shiny App for converting the pharmacokinetic parameters

Description

Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore,we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model.

Usage

PKconverterApp()

Examples

#PKconverterApp()

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with parameters (A, B, C, alpha, beta, and gamma) in two compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Coefficient_Exponent(A,B,C,alpha,beta,gamma,A.sd=NA,
   B.sd=NA,C.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,
   covar=c(AB=NA,AC=NA,Aalpha=NA,Abeta=NA,Agamma=NA,BC=NA,Balpha=NA,
   Bbeta=NA,Bgamma=NA,Calpha=NA,Cbeta=NA,Cgamma=NA,alphabeta=NA,
   alphagamma=NA,betagamma=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Coefficient_Exponent(A=12.2,B=3.76,C=1.44,
alpha=0.870,beta=0.12,gamma=0.013, A.sd=0.2,B.sd=0.005,C.sd=0.0005,
alpha.sd=0.009,beta.sd=0.006,gamma.sd=0.00005)

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distributions (V1, V2 and V3) and clearances (Cl1, Cl2, and Cl3)

Usage

ThreeComp_Volume_Clearance(V1,V2,V3,Cl1,Cl2,Cl3,
 V1.sd=NA,V2.sd=NA,V3.sd=NA, Cl1.sd=NA,Cl2.sd=NA,Cl3.sd=NA,
 covar=c(V1V2=NA,V1V3=NA,V1Cl1=NA,
   V1Cl2=NA,V1Cl3=NA,V2V3=NA,V2Cl1=NA,V2Cl2=NA,V2Cl3=NA,
   V3Cl1=NA,V3Cl2=NA,V3Cl3=NA,Cl1Cl2=NA,Cl1Cl3=NA,Cl2Cl3=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance(V1=10,V2=100,V3=1000,Cl1=3,Cl2=2,Cl3=1,
  V1.sd=0.01,V2.sd=0.1,V3.sd=1,Cl1.sd=0.01,Cl2.sd=0.01,Cl3.sd=0.01)

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distributions (Vd and V1), clearance (Cl1) and half-lives (t_alpha, t_beta, and t_gamma)

Usage

ThreeComp_Volume_Clearance_HalfLife(V1,Vd,Cl1,t_alpha,t_beta,t_gamma,
 V1.sd=NA,Vd.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,t_beta.sd=NA,t_gamma.sd=NA,
 covar=c(V1Vd=NA,V1Cl1=NA,V1talpha=NA,V1tbeta=NA,V1tgamma=NA,VdCl1=NA,
   Vdtalpha=NA,Vdtbeta=NA,Vdtgamma=NA,Cl1talpha=NA,Cl1tbeta=NA,
   Cl1tgamma=NA,talphatbeta=NA,talphatgamma=NA,tbetatgamma=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance_HalfLife(V1=5,Vd=1110,Cl1=3,
t_alpha=1.142,t_beta=52.2,t_gamma=931, V1.sd=0.01,Vd.sd=20,Cl1.sd=0.01,
t_alpha.sd=0.002,t_beta.sd=0.5,t_gamma.sd=5.6)

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12 and k31), and parameters (alpha, beta and gamma) in the model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Volume_Exponent(V1,alpha,beta,gamma,k21,k31,
 V1.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,k21.sd=NA,k31.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1gamma=NA,V1k21=NA,V1k31=NA,
   alphabeta=NA,alphagamma=NA,alphak21=NA,alphak31=NA,
   betagamma=NA,betak21=NA,betak31=NA,gammak21=NA,gammak31=NA,
   k21k31=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Exponent(V1=10,alpha=0.6, beta=0.013, gamma=0.00074,
   k21=0.02, k31=0.001, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,
   gamma.sd=0.000002, k21.sd=0.0006,k31.sd=0.0000005)

Convert pharmacokinetic parameters for three compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k13, k21, and k31)

Usage

ThreeComp_Volume_RateConstant(V1,k10,k12,k13,k21,k31,
 V1.sd=NA,k10.sd=NA,k12.sd=NA,
 k13.sd=NA,k21.sd=NA,k31.sd=NA,covar=c(V1k10=NA,V1k12=NA,V1k13=NA,
   V1k21=NA,V1k31=NA,k10k12=NA,k10k13=NA,k10k21=NA,k10k31=NA,
   k12k13=NA,k12k21=NA,k12k31=NA,k13k21=NA,k13k31=NA,k21k31=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_RateConstant(V1=10,k10=0.3,k12=0.2,k13=0.1,k21=0.02,
         k31=0.001,V1.sd=0.1,k10.sd=0.002,k12.sd=0.001,
         k13.sd=0.0005,k21.sd=0.0005,k31.sd=0.000005)

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with parameters (A, B, alpha and beta) in two compartment model "Aexp(-alpha)+Bexp(-beta)"

Usage

TwoComp_Coefficient_Exponent(A,B,alpha,beta,
 A.sd=NA,B.sd=NA,alpha.sd=NA,beta.sd=NA,
 covar=c(AB=NA,Aalpha=NA,Abeta=NA,Balpha=NA,Bbeta=NA,alphabeta=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Coefficient_Exponent(A=0.196,B=0.0036,alpha=1.221,beta=0.0287,
A.sd=0.002,B.sd=0.00005,alpha.sd=0.09,beta.sd=0.0006)

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distributions (V1 and V2) and clearances (Cl1 and Cl2)

Usage

TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2,
                  V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA,
                  covar=c(V1V2=0,V1Cl1=0,V1Cl2=0,
                    V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5,
         V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), clearance (Cl1) and half-lives (t_alpha and t_beta)

Usage

TwoComp_Volume_Clearance_HalfLife(V1,Cl1,t_alpha,t_beta,
 V1.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,
 t_beta.sd=NA,covar=c(V1Cl1=NA,V1talpha=NA,V1tbeta=NA,Cl1talpha=NA,
   Cl1tbeta=NA,talphatbeta=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Clearance_HalfLife(V1=5,Cl1=3.5,t_alpha=0.568,t_beta=24.2,
V1.sd=0.01,Cl1.sd=0.01,t_alpha.sd=0.002,t_beta.sd=0.5)

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12), and parameters (alpha and beta) in the model "Aexp(-alpha)+Bexp(-beta)"

Usage

TwoComp_Volume_Exponent(V1,alpha,beta,k21,V1.sd=NA,
 alpha.sd=NA,beta.sd=NA,k21.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1k21=NA,alphabeta=NA,
 alphak21=NA,betak21=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Exponent(V1=5,alpha=1.221, beta=0.029, k21=0.05,
V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,k21.sd=0.0006)

Convert pharmacokinetic parameters for two compartment model

Description

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k21)

Usage

TwoComp_Volume_RateConstant(V1,k10,k12,k21,
              V1.sd=NA,k10.sd=NA,k12.sd=NA,k21.sd=NA,
              covar=c(V1k10=NA,V1k12=NA,V1k21=NA,
              k10k12=NA,k10k21=NA,k12k21=NA),...)

Arguments

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_RateConstant(V1=5,k10=0.7,k12=0.5,k21=0.05,
         V1.sd=0.01,k10.sd=0.002,k12.sd=0.001,k21.sd=0.0005)